Pharmaceutical compound.



entran eTAfrus PATENT oriana.,

WLHELM HIEMENZ iA1\mLUDWIG TAUB, 0F ELBERFELD, GERMANY, Assis-Nous To FARBENFABRIKEN VORM. FRIEDR. BAYER @e oo., 0F ELBERFELD, GERMANY, A

CRPORATION 0F GERMANY.

PHARMACEUTICAL COMPOUND.

emesse.

No Drawing.

To all whom i may concern Be it known that We, VILHELM HIEMENZ, and LUDWIG TAUB, doctors of philosophy, chemists, citizens ot' the German Empire, residing' at Elberfeld, Germany, have invented new and useful Improvements in New Pharl'naeeutieal Compounds, of which the following is a specification.

lVe have found that `the hitherto unknown noiezroiiiatie amids and ureids (carbamid derivatives) of high-molecular halogen substituted fatty acids are therapeutically valuable products which are tasteless stable compounds and give oft iodin or bromin in the organism. They have proved to be valuable remedies in medicine, an average dose being, from 1-2 grains.

The process for producing the new com pounds consists in converting,1 according to the usual methods into the amids or ureids the higlrmoleoular 'fatty acids or their derivatives substituted by bromin or iodin.

.ln order to illustrate the new process more :t'ully the following example is given, 4the parts being by weightzl() parts ol diiodoln'assidio aeid are heated to 3U-(300 (l. to- @ether with 65 parts ot powdered phosphortins pentachlorid. Vhen the evolution ot" hydrochloric acid ceases, the chlorid is introduced while stirringV into a mixture ot ice and L00() parts o't a concentrated aqueous solution ofiammonia. The precipitate is re- Specfcation of Letters Patent.

Application filed September 14, 1911. Serial No. 649,286.

crystallized from alcohol. rl`he amid is almost insoluble in most solvents. It can be recrystallized from glacial acetic acid. Melting point. J2-i" (l. In the same manner the ehlorid can also be treated with amins e. g. diethylamin or urea.

The ureid ot dibroniobehenioacid melts at lLlJO C., the amid melts at 78 (1.,thea1ncl ol iodobehenio acid melts at 78o C.

lVe claimz l.- rPhe herein described ami'ls of dihalogen-substituted latty acids o't high molecular weight being;l solid stable compounds, tasteless and insoluble in water, snbstantially as described.

2. rlehe herein-described ainids ot' diiodo substituted t'atty acids ol high mole'fular weight, being` solid stable compounds, testeless and insoluble in water, substantially as described.

3. The herein described amid ot' diiodtbrassidic acid, beine' a Isolid stable eompound, tormiue' crystals melting at hilo (L, substantially as dcsf'ribcd.

ln testimony whereol \\'e have hereunto set. our hands in the presenee ot two subscribing \.\'ilnesses.

Witnesses:

Alanuz'r l". Nl'lluu, L. Noren. 

